About Biofile PDF Print E-mail

Biofile develops, manufactures and markets diagnostic tests to support the clinical diagnosis and monitoring of autoimmune and infectious diseases, as well as tolerance testing. Biofile research & development, production plant and clinical service laboratory operations are located in Turku, Finland.

Development and Production
Biofile products are based on traditional methods like ELISA and IFA technologies. Currently the production portfolio includes the Biofons Celiac Disease Panel and Biofons Inflammatory Bowel Disease Panel. Celiac Disease Panel contains five tests: AGA IgA and IgG, tTG IgA and IgG and Endomysium IgA (hUC) IFA test. New additions to Biofile production range are oral solutions for Glucose and Lactose tolerance tests.

Marketing
To support its product portfolio, Biofile imports and markets diagnostic kits - mainly to the Nordic countries and the Baltic region. In addition, the distribution to the other European Union countries and Middle East is growing rapidly.

Clinical Service Laboratory
Biofile also runs a clinical service laboratory in Finland offering quality determinations of Biofile assays as well as other, rare autoimmune determinations. For information about Biofile’s Service Laboratory, please visit Clinical Laboratory. This section is available in Finnish only.
 
Biofons Celiac Disease Panel PDF Print E-mail

Clinical symptoms and basis of diagnostics

Coeliac disease (CD) and Dermatitis Herpetiformis (DH) are autoimmune diseases with known environmental trigger and a strong genetic component. The external trigger is ingested wheat gluten or related proteins from rye, barley and possibly oats. CD is a multigenic disorder with a strong HLA association. HLA-DQ2 and DQ8 confer susceptibility together with as yet unidentified gene loci. Expression of HLA-DQ2 and DQ8 molecules that present gliadin-derived peptides to CD4 T cells is necessary but not sufficient to develop CD.
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